Started taking my new cholesterol meds this evening with dinner. From my experience, it takes anywhere between 3 to 10 days for my muscles and joints to start hurting from the statin. The first statin I ever took 4 years ago hit me in 10 days and all the others after that took less time to bring on the pain. I hope that this one won't cause pain, but if it does, I'm done with them forever. I know....I said that before, but I keep thinking that just maybe there is one out there that will not effect me like the others. Maybe I'm crazy too.